Lupus & antiphospholipid syndrome
Assessment of the role of high-density lipoproteins and their immunomodulatory activity in systemic lupus erythematosus immunopathology
Authors' conclusion
Our results suggest that HDL is essential for SLE beyond atherosclerosis and is related to inflammation regulation, possibly mediated by inflammasome immunomodulation.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and sex-matched healthy controls of similar age ranges
- Participants
- 50 vs 50
- Exposure
- SLE vs healthy controls
- SLEn = 50
- Healthy controlsn = 50reference
- Outcome
- Associations between HDL levels and inflammasome components in SLE
Methodological detailssex-matched healthy controls
- Sex-matched healthy controls
Main finding
As reported in the abstract
- HDL cholesterol (HDL-C) lower in SLE; lowest in active SLE
- Significant negative correlations between high-density lipoprotein (HDL) levels and disease activity, serum IL-6 and IL-1β levels and mRNA expression of NLRP3, IL-1β and IL-18
- SLE vs Healthy controls: P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Serum IL-1β and IL-6Higher concentrations in SLE | P < 0.0001 |
C reactive protein (CRP)
- Similar CRP levels in SLE and controls
Inflammasome gene expression in PBMCs
- All evaluated markers significantly upregulated in SLE
Correlations with disease activity
- Significant positive correlations between disease activity and serum IL-1β and IL-18 mRNA expression
- Significant positive correlations between active SLE and serum IL-1β and NLRP3 mRNA expression
Original publication
Assessment of the role of high-density lipoproteins and their immunomodulatory activity in systemic lupus erythematosus immunopathology. Lupus Sci Med. Published 25 July 2024. doi:10.
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