Lupus & antiphospholipid syndrome
Predictive value of Doppler echocardiography parameters for cardiovascular events in patients with systemic lupus erythematosus
Authors' conclusion
Doppler echocardiography is a valuable tool for the early diagnosis of left ventricular diastolic dysfunction in SLE patients. Key echocardiographic parameters, including LVMI, PWI + Tei, TDI-Tei, and GLS, are effective in predicting cardiovascular events
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and age- and gender-matched healthy individuals
- Participants
- 286 vs 100
- Comparison
- SLE patients vs age- and gender-matched healthy individuals
- SLEn = 286
- Controln = 100reference
- Outcome
- Doppler echocardiographic parameters, SLE vs healthy controls
Methodological detailsage- and gender-matched healthy controls, multivariate logistic regression
- Age- and gender-matched healthy controls
- Multivariate logistic regression
Main finding
As reported in the abstract
- Increased left ventricular posterior wall thickness (LVPWT), interventricular septal diameter (IVSD), left ventricular mass (LVM), LVM index (LVMI), peak A, PWI + Tei, E/e', TDI-Tei and decreased e' and E/A in SLE vs healthy controls
- p < .001
- LVMI, PWI + Tei, TDI-Tei and GLS significant predictors of cardiovascular events (multivariate logistic regression)
- p < .05
Observational data: associations, not effects.
Further findings
Inflammatory markers, SLE vs controls
- Higher CRP and lower complement C3 and C4 in SLE
- P < 0.001
Diastolic dysfunction by SLE activity and cardiovascular events (subgroup)
- More severe ventricular diastolic dysfunction with higher SLE activity and in those with cardiovascular events
Correlation of PWI + Tei, TDI-Tei and GLS with SLE activity and cardiovascular events
- Positive associations
- P < 0.01
Original publication
Predictive value of Doppler echocardiography parameters for cardiovascular events in patients with systemic lupus erythematosus. Lupus. Published 25 July 2024. doi:10.
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