Lupus & antiphospholipid syndrome
Comparison of predictive validity of the Lupus Patient-Reported Outcome and Short-Form-12 for damage accrual in systemic lupus erythematosus
Authors' conclusion
Predictive metrics and discriminatory performance were comparable between the Lupus PRO and SF-12.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE)
- Participants
- 1,326 patients
- Exposure
- Lupus PRO vs SF-12 for predicting damage accrual
- Outcome
- Damage accrual (increase of one unit in SLICC/ACR DI [SDI])
Methodological detailssurvival models for recurrent events
- Survival models for recurrent events
Main finding
As reported in the abstract
Damage accrual by baseline PRO score
Hazard ratio (95% CI)
Higher HR-QOL (Lupus PRO)
0.94(0.89–0.99)
Higher PCS (SF-12)
0.92(0.86–0.98)
Higher RCS (SF-12)
0.92(0.86–0.99)
Observational data: associations, not effects.
Further findings
- Only higher physical component summary (PCS) of SF-12 associated with GC-independent SDI
Original publication
Comparison of predictive validity of the Lupus Patient-Reported Outcome and Short-Form-12 for damage accrual in systemic lupus erythematosus. Rheumatology (Oxford). Published 6 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →