Lupus & antiphospholipid syndrome
Predictive validity of Lupus Patient-Reported Outcome for damage accrual in patients with systemic lupus erythematosus: the LUNA Registry
Main finding · Change in SDI with higher baseline HR-QOL of Lupus PROResult — go to the resultDifference in SDI increase −0.005 /year 95% CI −0.007 to −0.004Authors' conclusion
A higher HR-QOL of Lupus PRO was associated with a lower increase in SDI scores.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and ≥2 measurements over time, Japanese nationwide multicentre registry (LUNA)
- Participants
- 1,295 patients
- Exposure
- Higher vs lower baseline HR-QOL of Lupus Patient-Reported Outcome (PRO)
- Outcome
- Association between baseline Lupus PRO score and longitudinal SLICC/ACR DI (SDI) scores (damage accrual)
Methodological detailsmulticentre, nationwide registry, mixed-effects models adjusted for prognostic factors
- Multicentre
- Nationwide registry
- Mixed-effects models adjusted for prognostic factors
Main finding
As reported in the abstract
Change in SDI with higher baseline HR-QOL of Lupus PRO
Difference in SDI increase
−0.005 /year
95% CI −0.007 to −0.004
P < 0.001
Highervs lower baseline HR-QOL of Lupus PRO
difference in SDI increase −0.005 /year (95% CI −0.007 to −0.004); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Difference (/year) (95% CI) | |
|---|---|---|
| Longitudinal SDI by HR-QOL tertileSecond tertilevs First tertileDose-dependent effect | −0.101 (−0.172 to −0.030) | |
| Longitudinal SDI by HR-QOL tertileThird tertilevs First tertileDose-dependent effect | −0.211 (−0.281 to −0.142) | |
| −0.4−0.200.2Difference, /year (linear scale) |
Non-HR-QOL and SDI
- Non-HR-QOL not significantly associated with SDI scores
HR-QOL domains and total SDI
- Cognition, procreation and physical health significantly associated with total SDI over time
Corticosteroid-dependent and -independent SDI
- HR-QOL associated with corticosteroid-dependent and -independent SDI scores
Original publication
Predictive validity of Lupus Patient-Reported Outcome for damage accrual in patients with systemic lupus erythematosus: the LUNA Registry. Rheumatology (Oxford). Published 17 June 2024. doi:10.
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