Lupus & antiphospholipid syndrome
Gender differences in the clinical features and quality of life of Japanese patients with systemic lupus erythematosus: a cross-sectional study based on the LUNA registry
Authors' conclusion
Japanese male patients with SLE have a relatively higher HRQOL than females; however, this change became unclear in patients with SLE who had joint or cardiac damage.
Study context
- Population
- Japanese patients with systemic lupus erythematosus (SLE) enrolled in a nationwide multicentre registry (LUNA); median age 51 years (IQR 40–63)
- Participants
- 1,297 patients
- Exposure
- Male vs female patients with SLE
- Malesn = 159
- Femalesn = 1,138reference
- Outcome
- Gender differences in clinical features and HRQOL (LupusPRO)
Methodological detailsretrospective, multicentre, nationwide registry (LUNA)
- Retrospective
- Multicentre
- Nationwide registry (LUNA)
Main finding
As reported in the abstract
HRQOL (LupusPRO score)
Males
87.4
Females
80.5
P = 0.001
Observational data: associations, not effects.
Further findings
Articular/joint damage
P = 0.046
Cardiac damage
P = 0.015
HR QOL (HRQOL) in patients with arthritis/joint damage and cardiac damage (subgroups)
- Difference in HRQOL between sexes became unclear in the presence of arthritis/joint damage and cardiac damage
Disease characteristics
- Males had shorter disease duration and were older at onset
- Disease activity scores slightly lower in males; SDI slightly higher in females
Original publication
Gender differences in the clinical features and quality of life of Japanese patients with systemic lupus erythematosus: a cross-sectional study based on the LUNA registry. Arthritis Res Ther. Published 7 January 2026. doi:10.
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