Lupus & antiphospholipid syndrome
Interleukin-23 levels and their association with systemic lupus erythematosus: A systematic review and meta-analysis
Pooled result · Circulating IL-23 levels (pooled)Result — go to the resultMD 71.467 95% CI 26.44–116.49Authors' conclusion
This meta-analysis reveals a significant association between elevated IL-23 levels and SLE
Study context
- Population
- Observational studies comparing circulating IL-23 levels in SLE patients and healthy controls, with SLE Disease Activity Index (SLEDAI) for disease activity12 studies
- Participants
- 680 vs 416
- Comparison
- Circulating IL-23 levels in SLE vs healthy controls
- SLEn = 680
- Healthy controlsn = 416reference
- Outcome
- Circulating IL-23 levels, SLE vs healthy controls
Methodological detailstrial sequential analysis, sensitivity analysis, Newcastle-Ottawa Scale quality assessment
- Trial sequential analysis
- Sensitivity analysis
- Newcastle-Ottawa Scale quality assessment
Pooled result
Circulating IL-23 levels (pooled)
MD
71.467
95% CI 26.44–116.49
P = 0.002
SLEvs Healthy controls
MD 71.467 (95% CI 26.44–116.49); P = 0.002
As reported in the abstract
Further pooled results
| Outcome | MD | P value |
|---|---|---|
| IL-23 levels, active vs inactive SLEStatistically insignificant | 27.777 | P = 0.085 |
Correlation of IL-23 with SLEDAI scores
- Correlation coefficient (p = 0.027)
- 0.510
Ethnicity-specific analysis
- Similar trends in East Asian and Middle Eastern populations
Original publication
Interleukin-23 levels and their association with systemic lupus erythematosus: A systematic review and meta-analysis. Lupus. Published 6 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →