Lupus & antiphospholipid syndrome
Genetically predicted circulating interleukin-18 levels are associated with risk of systemic lupus erythematosus and type 1 diabetes
Authors' conclusion
Our analyses suggest that circulating IL-18 is significantly related to SLE and T1D
Study context
- Population
- Individuals of European descent (genome-wide association study (GWAS) of circulating IL-18 levels)GWAS for IL-18 instrumental variables (IVs)
- Participants
- 21,758 individuals
- Comparison
- Genetically predicted circulating IL-18 levels and risk of inflammatory and autoimmune diseases
- Outcome
- Risk of inflammatory and autoimmune diseases
Methodological detailsinverse-variance weighted method, GWAS-derived instrumental variables
- Inverse-variance weighted method
- GWAS-derived instrumental variables
Main finding
As reported in the abstract
Causal association of IL-18 with disease risk (inverse-variance weighed (IVW))
Odds ratio (95% CI)P value
SLE
1.32(1.15–1.50)
P < 0.001T1D
1.22(1.06–1.42)
P = 0.007Further findings
Sensitivity analyses
- No significant heterogeneity or horizontal pleiotropy for systemic lupus erythematosus (SLE) and T1D
- Removing confounding SNP produced similar results for SLE and T1D
- Leave-one-out: no single SNP significantly influenced results
Original publication
Genetically predicted circulating interleukin-18 levels are associated with risk of systemic lupus erythematosus and type 1 diabetes. Lupus. Published 26 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →