Lupus & antiphospholipid syndrome
The potential causal association between systemic lupus erythematosus and endocrine and metabolic disorders in the East Asian population: A bidirectional two-sample Mendelian randomization study
Authors' conclusion
We confirmed that SLE has a causal effect on GD as well as OP, but no evidence exists to substantiate a causal link between SLE and T2DM.
Study context
- Population
- East Asian population (GWAS data for systemic lupus erythematosus (SLE), Graves' disease (GD), T2DM and osteoporosis (OP))
- Comparison
- Genetically predicted SLE vs Graves' disease, T2DM and osteoporosis
- Outcome
- Causal association between SLE and GD, T2DM and OP
Methodological detailsgenome-wide association study data, sensitivity analysis
- Genome-wide association study data
- Sensitivity analysis
Main finding
As reported in the abstract
SLE on GD risk (multiplicative random-effect inverse-variance weighted (IVW)), OR
1.12
95% CI 1.04–1.22p < .01
SLE on OP risk (IVW), OR
1.035
95% CI 1.003–1.068p < .05
Further findings
Reverse direction: GD on SLE
- IVW after Bonferroni correction, OR
- 1.33 (95% CI 1.19-1.49, p < .05/3)
- Multivariable Mendelian randomization (MR): no causal association, OR
- 1.047 (95% CI 0.952-1.151, p > .05)
Sensitivity analysis
- Robustness and validity of findings verified
Original publication
The potential causal association between systemic lupus erythematosus and endocrine and metabolic disorders in the East Asian population: A bidirectional two-sample Mendelian randomization study. Lupus. Published 12 January 2024. doi:10.
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