Lupus & antiphospholipid syndrome
The potential causal association of systemic lupus erythematosus with congestive heart failure in the East Asian population: A two-sample mendelian randomization study
Main finding · CHF risk with genetic susceptibility to SLEResult — go to the resultOdds ratio 1.032 95% CI 1.004–1.061Authors' conclusion
The findings of this MR study suggest that SLE potentially increases the risk of CHF in the East Asian population.
Study context
- Population
- East Asian population; GWAS datasets for systemic lupus erythematosus (SLE) (4222 cases, 8431 controls) and congestive heart failure (CHF) (9413 cases, 203,040 controls)
- Comparison
- Genetic susceptibility to SLE and risk of congestive heart failure
- Outcome
- Congestive heart failure (CHF)
Methodological detailsEast Asian GWAS datasets, MR sensitivity analyses
- East Asian GWAS datasets
- MR sensitivity analyses
Main finding
CHF risk with genetic susceptibility to SLE
Odds ratio
1.032
95% CI 1.004–1.061
P = 0.023
Genetic susceptibility to SLE
OR 1.032 (95% CI 1.004–1.061); P = 0.023
As reported in the abstract
Further findings
CHF after excluding human leukocyte antigen (HLA) regions
| OR (95% CI) | P value | ||
|---|---|---|---|
| SLE | 1.034 (1.007–1.062) | P = 0.015 | |
| 0.512Odds ratio (log scale) |
Original publication
The potential causal association of systemic lupus erythematosus with congestive heart failure in the East Asian population: A two-sample mendelian randomization study. Lupus. Published 4 January 2023. doi:10.
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