Lupus & antiphospholipid syndrome
Assessment of bidirectional relationships between systemic lupus erythematosus and anxiety disorder: A two-sample Mendelian randomization study
Authors' conclusion
Bidirectional two-sample MR study does not support the causal relationship between SLE and anxiety disorder.
Study context
- Population
- Genome-wide association studies (GWAS) summary data of systemic lupus erythematosus (SLE) and anxiety disorder, European ancestry2 GWAS
- Comparison
- Genetically predicted SLE and anxiety disorder, in both directions
- Outcome
- Causal effect of genetically predicted SLE on anxiety disorder risk (and reverse), by IVW
Methodological detailsInverse variance-weighted (IVW) main method, MR-Egger, weighted median, simple mode, weighted mode supplementary, MR-pleiotropy residual sum and outlier (MR-PRESSO) outlier exclusion
- IVW main method
- MR-Egger, weighted median, simple mode, weighted mode supplementary
- MR-PRESSO outlier exclusion
Main finding
As reported in the abstract
Genetically predicted SLE → anxiety disorder risk (IVW), OR
1.000
95% CI 0.992 to 1.008p =.997
Anxiety disorder → SLE risk (IVW), OR
1.000
95% CI 0.992 to 1.008p = .997
Further findings
Supplementary Mendelian randomization (MR) methods
- Similar result
Sensitivity analysis (Cochran's Q, MR-Egger intercept, leave-one-out)
- High stability of the result
Original publication
Assessment of bidirectional relationships between systemic lupus erythematosus and anxiety disorder: A two-sample Mendelian randomization study. Lupus. Published 1 February 2023. doi:10.
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