Lupus & antiphospholipid syndrome
Telomere length and its association with systemic lupus erythematosus in an Asian population: A Mendelian randomization study
Authors' conclusion
Our findings provided evidence supporting a potential causal relationship between longer telomere length and increased risk of systemic lupus erythematosus.
Study context
- Population
- Asian population: Genome-wide association study (GWAS) of 6,707 systemic lupus erythematosus (SLE) cases and 16,047 controls6,707 cases
- Comparison
- Genetically predicted longer vs shorter telomere length
- Outcome
- SLE risk with longer genetically predicted telomere length (IVW)
Methodological detailstwo-sample, random-effects inverse-variance weighted (IVW) (main analysis), MR-Egger regression for horizontal pleiotropy
- Two-sample
- Random-effects IVW (main analysis)
- MR-Egger regression for horizontal pleiotropy
Main finding
As reported in the abstract
OR, 95%CI 1.21, 2.46, p = 0.01
1.72
Further findings
Horizontal pleiotropy (MR-Egger intercept)
- Intercept, p = 0.69; no evidence of horizontal pleiotropy
- 0.017
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Telomere length and its association with systemic lupus erythematosus in an Asian population: A Mendelian randomization study. Lupus. Published 19 August 2023. doi:10.
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