Lupus & antiphospholipid syndrome
Lupus Low Disease Activity State and organ damage in relation to quality of life in systemic lupus erythematosus: a cohort study with up to 11 years of follow-up
Authors' conclusion
In one of the longest observational studies to date, we demonstrated that low disease activity and being sustainedly in LLDAS were coupled with favourable HRQoL, pain, fatigue and overall health experience, irrespective of organ damage.
Study context
- Population
- Patients with SLE from a tertiary referral centre
- Participants
- 327 patients
- Exposure
- Lupus Low Disease Activity State (LLDAS) attainment, disease activity and organ damage in relation to patient-reported outcomes (PROs)
- Outcome
- HRQoL by EQ-5D-3L and VAS scores for fatigue, pain and overall SLE-related health state
Methodological detailssingle-centre (tertiary referral centre), median follow-up 8.5 years
- Single-centre (tertiary referral centre)
- Median follow-up 8.5 years
Main finding
As reported in the abstract
Association of LLDAS, disease activity and organ damage with PROs
- LLDAS attainment, lower physician global assessment (PhGA) and lower clinical SLEDAI-2K associated with favourable health-related quality of life (HRQoL) by EQ-5D-3L and visual analogue scale (VAS) (overall population, recent-onset SLE and clinically active, autoantibody-positive subgroups)
- Increasing SLICC/ACR damage index (SDI) associated with poor PROs, except fatigue in the overall population
- PROs further enhanced by sustained LLDAS
- In fully adjusted models, LLDAS attainment and lower disease activity associated with favourable PROs, irrespective of SDI
Observational data: associations, not effects.
Original publication
Lupus Low Disease Activity State and organ damage in relation to quality of life in systemic lupus erythematosus: a cohort study with up to 11 years of follow-up. Rheumatology (Oxford). Published 24 February 2024. doi:10.
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