Lupus & antiphospholipid syndrome
Therapeutic strategies and outcomes in neuropsychiatric systemic lupus erythematosus: an international multicentre retrospective study
Authors' conclusion
NP manifestations attributed to SLE by clinical judgment and treated with immunosuppressants demonstrated improved 12-month outcomes.
Study context
- Population
- Patients with neuropsychiatric systemic lupus erythematosus (NPSLE) experiencing their first neuropsychiatric (NP) manifestation350 events
- Outcome
- Clinical outcome of NP events (physician seven-point Likert scale); predictors of clinical improvement/resolution
- Follow-up
- 12 months
Methodological detailsinternational, multicentre, multivariable logistic regression
- International
- Multicentre
- Multivariable logistic regression
Main finding
As reported in the abstract
Clinical improvement in NP manifestations
Patients with clinical improvement in NP manifestations
64%
Observational data: associations, not effects.
Further findings
Treatment
- Immunosuppressants and corticosteroids more frequently initiated/escalated for SLE-attributed central diffuse or focal NP manifestations
Original publication
Therapeutic strategies and outcomes in neuropsychiatric systemic lupus erythematosus: an international multicentre retrospective study. Rheumatology (Oxford). Published 24 February 2024. doi:10.
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