Lupus & antiphospholipid syndrome
Positivity of antiphosphatidylserine/prothrombin antibodies identifies a subgroup of more severe antiphospholipid syndrome patients
Authors' conclusion
The increased thrombotic risk associated with the aPS/PT antibodies would justify their testing in all APS patients in complementarity with the conventional anti-phospholipid antibodies to propose the best-adjusted treatment.
Study context
- Population
- Patients with thrombosis (64 with known antiphospholipid syndrome (APS) per Sydney criteria) or aPL positivity (mainly lupus anticoagulant (LA)) without clinical APS, tested for anti-PS/PT, March 2019–May 2020; active neoplasia excluded128 with thrombosis
- Participants
- 148 patients
- Exposure
- Anti-PS/PT positive vs negative patients
- Outcome
- Characterisation of anti-PS/PT and/or anti-PT-antibody-positive patients in terms of APS severity and organ damage
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
Clinical features, anti-PS/PT positive vs negative
- No particular thrombotic phenotype in anti-PS/PT positive patients
- Anti-PS/PT positive vs Anti-PS/PT negative: P = 0.01
- Anti-PS/PT positive vs Anti-PS/PT negative: P = 0.04
- Anti-PS/PT positive vs Anti-PS/PT negative: P = 0.03
- Anti-PS/PT positive vs Anti-PS/PT negative: P = 0.001
- Notably in the associated-APS patient group
Observational data: associations, not effects.
Further findings
Tetra-positivity (LA+, anti-cardiolipin (aCL)+, a2βGPI+, anti-PS/PT+) and APS severity
- Associated with more severe APS (thrombotic recurrences, thrombosis under anticoagulant treatment, trend of more frequent catastrophic APS)
Anti-PT antibody positivity
- Agreement with anti-PS/PT antibodies
- 58.7%
- Similar phenotype to a lesser extent
Original publication
Positivity of antiphosphatidylserine/prothrombin antibodies identifies a subgroup of more severe antiphospholipid syndrome patients. Clin Exp Rheumatol. Published 22 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →