Lupus & antiphospholipid syndrome
Determination of four homogeneous subgroups of patients with antiphospholipid syndrome: a cluster analysis based on 509 cases
Authors' conclusion
Our study applied an unsupervised clustering method to distinguish four homogeneous APS patient subgroups that were predominantly venous; arterial; associated with SLE or another autoimmune disease; and arterial microthrombotic.
Study context
- Population
- APS patients meeting the Sydney classification criteria, French multicentre 'APS and SLE' registry77.8% women
- Participants
- 509 patients
- Exposure
- Cluster 1 vs Cluster 2 vs Cluster 3 vs Cluster 4
- Outcome
- Distinct homogeneous phenotypes among APS patients by unsupervised hierarchical cluster analysis
Methodological detailsobservational, multicentre, unsupervised multiple correspondence analysis followed by hierarchical ascendant clustering, 27 variables
- Observational
- Multicentre
- Unsupervised multiple correspondence analysis followed by hierarchical ascendant clustering
- 27 variables
Main finding
As reported in the abstract
Homogeneous APS phenotype clusters
- Four homogeneous groups of patients identified: predominantly venous; arterial; associated with SLE or another autoimmune disease; and arterial microthrombotic
- 4
Observational data: associations, not effects.
Further findings
- Deaths — Cluster 4
- 16.7%
- Deaths: more deaths in cluster 4
Age at APS diagnosis and follow-up since diagnosis
- Mean (SD) age at APS diagnosis, years
- 36.2 (14.6)
- Mean (SD) follow-up since diagnosis, years
- 10.3 (8.5)
Original publication
Determination of four homogeneous subgroups of patients with antiphospholipid syndrome: a cluster analysis based on 509 cases. Rheumatology (Oxford). Published 3 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →