Lupus & antiphospholipid syndrome
Pilot study on accelerated aging in lupus using epigenetic biomarkers of age
Authors' conclusion
We did not observe any evidence of an accelerated biological aging in SLE patients, according to Horvath's epigenetic clock model.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients and controls in two publicly available DNA methylation datasets2 datasets: 30 (15 SLE) and 55 (30 SLE)
- Comparison
- SLE vs controls
- Primary endpoint
- Epigenetic age acceleration according to Horvath's epigenetic clock model
Methodological detailssecondary analysis of public DNA methylation datasets, publicly available datasets, two datasets
- Secondary analysis of public DNA methylation datasets
- Publicly available datasets
- Two datasets
Primary result
As reported in the abstract
Epigenetic age acceleration (Horvath's clock)
- No statistically significant difference in epigenetic age acceleration between SLE patients and controls
Further findings
Correlation between chronological and epigenetic age
- Statistically significant correlation in both datasets
Original publication
Pilot study on accelerated aging in lupus using epigenetic biomarkers of age. Lupus. Published 30 September 2022. doi:10.
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