Lupus & antiphospholipid syndrome
Cluster analysis of clinical manifestations assigns systemic lupus erythematosus-phenotype subgroups: A multicentre study on 440 patients
Authors' conclusion
This unsupervised clustering method distinguished three distinct SLE patient subgroups, highlighting SLE heterogeneity.
Study context
- Population
- Systemic lupus erythematous (SLE) patients meeting Systemic Lupus International Collaborating Clinics (SLICC) classification criteria in the French multicentre "APS and SLE" Registry; mostly women (94.3%); median age at SLE diagnosis 24 (IQR 19–32) years
- Participants
- 440 patients
- Exposure
- Cluster 1 vs Cluster 2 vs Cluster 3
- Cluster 1n = 91
- Cluster 2n = 221
- Cluster 3n = 128
- Outcome
- Distinct, homogeneous SLE phenotypes by cluster analysis of 29 clinical and laboratory variables (excluding autoantibodies)
Methodological detailsmulticentre, registry-based, unsupervised multiple correspondence analysis, hierarchical ascendent-clustering analysis
- Multicentre
- Registry-based
- Unsupervised multiple correspondence analysis
- Hierarchical ascendent-clustering analysis
Main finding
As reported in the abstract
SLE phenotype clusters
- Three distinct subgroups based on cumulative clinical manifestations, not autoantibody pattern
- 3
Observational data: associations, not effects.
Original publication
Cluster analysis of clinical manifestations assigns systemic lupus erythematosus-phenotype subgroups: A multicentre study on 440 patients. Joint Bone Spine. Published 6 July 2024. doi:10.
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