Lupus & antiphospholipid syndrome
Phenotypically driven subgroups of primary antiphospholipid syndrome-associated thrombocytopenia display distinct outcomes: a prospective cohort study with cluster analysis
Authors' conclusion
Significant heterogeneity exists in patients with aPLs-TP, thus making PLT count alone an inadequate predictor of clinical phenotypes and prognosis.
Study context
- Population
- Patients with aPLs-TP (persistent aPL positivity ≥12 weeks apart, platelet (PLT) <100×109/L twice, secondary causes excluded), Peking Union Medical College Hospital, January 2012 to April 202465.9% female, mean age 36.0 years
- Participants
- 123 patients
- Exposure
- Three phenotypic clusters of aPLs-TP compared for clinical outcomes
- Cluster 1n = 35
- Cluster 2n = 51
- Cluster 3n = 37
- Outcome
- Event-free survival for key clinical outcomes:
- Thrombosis
- Pregnancy morbidity
- Microangiopathy
- Valve disease
- Follow-up
- 5 years
Methodological detailssingle-centre, consecutive enrolment, hierarchical clustering, Kaplan-Meier survival analysis
- Single-centre
- Consecutive enrolment
- Hierarchical clustering
- Kaplan-Meier survival analysis
Main finding
As reported in the abstract
Event-free survival for key clinical outcomes
P = 0.026
Observational data: associations, not effects.
Further findings
- Cluster 1 had the highest rate of atherothrombotic and valvular events
- Cluster 3 had the lowest rate of complete remission
Original publication
Phenotypically driven subgroups of primary antiphospholipid syndrome-associated thrombocytopenia display distinct outcomes: a prospective cohort study with cluster analysis. Lupus Sci Med. Published 13 November 2025. doi:10.
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