Lupus & antiphospholipid syndrome
Diagnostic value of cerebrospinal fluid antisuprabasin antibody in neuropsychiatric systemic lupus erythematosus
Authors' conclusion
CSF anti-SBSN antibody was significantly elevated in NPSLE and demonstrated good diagnostic performance for identifying NPSLE among patients with SLE presenting with neuropsychiatric symptoms.
Study context
- Population
- Patients with SLE presenting with new-onset neuropsychiatric or neurological symptoms, screened January 2022 to October 2025190 screened
- Participants
- 148 patients
- Comparison
- Cerebrospinal fluid (CSF) anti-SBSN antibody for identifying NPSLE vs non-NPSLE comparators
- NPSLEn = 48
- SLE with central nervous system infection (SLE-CNSI)n = 59reference
- SLE-Othern = 41reference
- Outcome
- Diagnostic performance of CSF anti-SBSN antibody (ELISA) for identifying NPSLE against combined non-NPSLE comparators
Methodological detailssingle-centre, prospective cohort, adjudication committee blinded to CSF anti-SBSN antibody results
- Single-centre
- Prospective cohort
- Adjudication committee blinded to CSF anti-SBSN antibody results
Performance
As reported in the abstract
Diagnostic performance of CSF anti-SBSN antibody, NPSLE vs non-NPSLE comparators
| Test or model | AUROC | Sensitivity | Specificity | Optimal cut-off |
|---|---|---|---|---|
| NPSLE | 0.830 | 0.812 | 0.740 | 76.36 ng/mL |
NPSLE
AUROC0.830
Sensitivity0.812
Specificity0.740
Optimal cut-off76.36 ng/mL
Further findings
CSF anti-SBSN antibody levels
| Outcome | AUROC | P value |
|---|---|---|
| AUROC, CSF anti-SBSN antibody vs other markersCSF anti-SBSN antibody vs CSF white blood cell count | 0.830 vs 0.743 | P = 0.041 |
| AUROC, CSF anti-SBSN antibody vs other markersCSF anti-SBSN antibody vs Serum antiribosomal P antibody | 0.830 vs 0.665 | P = 0.003 |
| AUROC, CSF anti-SBSN antibody vs other markersThree-marker model vs CSF anti-SBSN antibody alone | 0.892 | P = 0.009 |
- CSF anti-SBSN antibody levels — Stepwise increase across groups; all pairwise comparisons significant
- all p<0.001
- AUROC, CSF anti-SBSN antibody vs other markers: three-marker model significantly outperformed CSF anti-SBSN alone
Original publication
Diagnostic value of cerebrospinal fluid antisuprabasin antibody in neuropsychiatric systemic lupus erythematosus. Lupus Sci Med. Published 6 August 2026. doi:10.
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