Lupus & antiphospholipid syndrome
Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study
Authors' conclusion
The serum NfL levels may be a readily available marker of neuropsychiatric involvement in SLE.
Study context
- Population
- Patients with SLE and controls with paired serum and cerebrospinal fluid (CSF) samples
- Participants
- 80 SLE patients
- Exposure
- NPSLE vs non-NPSLE vs controls
- NPSLEn = 32
- non-NPSLEn = 16
- Controlsn = 31reference
- Outcome
- Serum NfL
Main finding
As reported in the abstract
NPSLE vs non-NPSLE: P < 0.05 · NPSLE vs Controls: P < 0.01
Observational data: associations, not effects.
Further findings
CSF NfL (upward trend in NPSLE)
Correlation of serum and CSF NfL in NPSLE
- R
- 0.8686, p<0.01
Serum NfL linked to elevated serum triacylglycerol, CRP and organ damage
- Triacylglycerol
- P = 0.002
- CRP
- P < 0.001
- Organ damage
- P = 0.036
CSF NfL linked to elevated serum triacylglycerol, CRP and organ damage
- Triacylglycerol
- P = 0.008
- CRP
- P = 0.007
- Organ damage
- P < 0.001
Correlation of intrathecal NfL and CSF IL-6 in NPSLE
- R
- 0.5118, p<0.05
Original publication
Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study. Lupus Sci Med. Published 19 January 2025. doi:10.
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