Lupus & antiphospholipid syndrome
Overlap syndrome of anti-aquaporin-4 positive neuromyelitis optica spectrum disorder and systemic lupus erythematosus: A systematic review of individual patient data
Authors' conclusion
AQP4+NMOSD in SLE patients is a relapsing and neurologically disabling disorder that can mimic neuropsychiatric manifestations, frequently occurs after the onset of lupus or may predate, responds to immunosuppressants, and necessitates indefinite treatment.
Study context
- Population
- Patients with AQP4+ neuromyelitis optica spectrum disorder (NMOSD) and systemic lupus erythematosus (SLE) overlap (AQP4 or NMO positivity in blood and/or cerebrospinal fluid (CSF), ≥1 manifestation of both NMOSD and SLE)case reports/series
- Participants
- 46 patients
- Outcome
- Clinical features and course of AQP4+ NMOSD/SLE overlap
Methodological detailscase reports and case series
- Case reports and case series
Pooled result
As reported in the abstract
- Female
- 42 out of 46 patients (91.3%)
- NMOSD onset after lupus
- 47.8%
- Median time between the two diagnoses
- 5 years
- Hematological manifestations
- 63%
- Longitudinally extensive transverse myelitis
- 87%
- Brainstem involvement on imaging
- 29.6%
- Relapsing course in the majority; monophasic course
- one patient
Original publication
Overlap syndrome of anti-aquaporin-4 positive neuromyelitis optica spectrum disorder and systemic lupus erythematosus: A systematic review of individual patient data. Lupus. Published 24 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →