Lupus & antiphospholipid syndrome
Reduced homovanillic acid, SDF-1α and SCGF-β levels in cerebrospinal fluid are related to depressive states in systemic lupus erythematosus
Authors' conclusion
Many patients with active SLE have subclinical depression, and MADRS evaluation of neuropsychiatric symptoms is useful for detecting them. Additionally, the decrease in CSF levels of HVA, SDF-1 α and SCGF-1β reflects the same pathology, and these may serve as surrogate markers.
Study context
- Population
- SLE patients enrolled 2017–2020 with high disease activity, abnormal CSF, brain MRI or electroencephalography findings, or history of neuropsychiatric illness7 with diffuse neuropsychiatric SLE (NPSLE)
- Participants
- 44 patients
- Exposure
- MADRS-positive vs MADRS-negative SLE patients
- MADRS-positiven = 20
- MADRS-negativen = 24reference
- Outcome
- PSYRATS positivity rate in SLE patients not diagnosed with diffuse NPSLE
Main finding
As reported in the abstract
PSYRATS positivity in SLE without diffuse NPSLE
Psychiatric symptom rating scales (PSYRATS) positive, 13 of 37 SLE patients without diffuse NPSLE
35.1%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| CSF HVA, SDF-1α and SCGF-1β concentrationsMADRS-positive vs MADRS-negative | P = 0.0400 |
| CSF HVA, SDF-1α and SCGF-1β concentrationsMADRS-positive vs MADRS-negative | P = 0.0431 |
| CSF HVA, SDF-1α and SCGF-1β concentrationsMADRS-positive vs MADRS-negative | P = 0.0061 |
- CSF homovanillic acid (HVA), SDF-1α and SCGF-1β concentrations — HVA, SDF-1α and SCGF-1β levels correlated with one another
- P < 0.05
Original publication
Reduced homovanillic acid, SDF-1α and SCGF-β levels in cerebrospinal fluid are related to depressive states in systemic lupus erythematosus. Rheumatology (Oxford). Published 28 February 2023. doi:10.
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