Lupus & antiphospholipid syndrome
The pathogenic role of lupus-specific autoantibodies and Interleukin-6 on demyelination of the brainstem and spinal cord in systemic lupus erythematosus
Authors' conclusion
CSF IL-6 could be a surrogating marker for disease activity, and serum anti-Smith antibody permeabilizes the BBB in patients with NPSLE, supporting the development of NMOSD-like CNS lesions.
Study context
- Population
- Patients with NPSLE with neuromyelitis optica spectrum disorder (NMOSD)-like demyelinating lesions in the brainstem and/or spinal cord
- Participants
- 12 patients
- Outcome
- CSF IL-6 levels before vs after treatment
Main finding
As reported in the abstract
P = 0.008
Observational data: associations, not effects.
Further findings
Atypical NMOSD (specific lesions, anti-aquaporin 4 antibody negative) subgroup: correlations with serum anti-Smith antibody titer before treatment
- Significant correlation of anti-Smith titer with cerebrospinal fluid (CSF) IL-6 (p = 0.025)
- Significant correlation of anti-Smith titer with QAlb (p = 0.033)
Original publication
The pathogenic role of lupus-specific autoantibodies and Interleukin-6 on demyelination of the brainstem and spinal cord in systemic lupus erythematosus. Lupus. Published 11 January 2023. doi:10.
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