Lupus & antiphospholipid syndrome
Evaluation of the EULAR /American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus in a Population‐Based Registry
Authors' conclusion
Applying the 3 commonly used classification criteria to a population-based registry identified patients with SLE fulfilling only 1 validated definition. The most recently developed EULAR/ACR classification criteria revealed prevalence and incidence estimates similar to those previously established for the ACR and SLICC classification schemes.
Study context
- Population
- Systemic lupus erythematosus (SLE) cases in the Manhattan Lupus Surveillance Program, a multiracial/ethnic population-based registryfulfilled ≥1 of 3 criteria
- Participants
- 1,497 cases
- Exposure
- 1997 ACR vs Systemic Lupus International Collaborating Clinics (SLICC) vs EULAR/ACR classification criteria for SLE
- Outcome
- Cases uniquely fulfilling each criteria set and fulfilling all 3; prevalence and incidence of SLE using the EULAR/ACR criteria
Methodological detailsmultiracial/ethnic population-based registry, Manhattan Lupus Surveillance Program
- Multiracial/ethnic population-based registry
- Manhattan Lupus Surveillance Program
Main finding
As reported in the abstract
Cases by classification criteria fulfilled
- Meeting all 3 classifications
- 1,008 (67.3%)
- EULAR/ACR age-adjusted overall prevalence per 100,000
- 59.6 (95% CI 55.9-63.4)
- EULAR/ACR age-adjusted overall incidence per 100,000
- 4.9 (95% CI 4.3-5.5)
Observational data: associations, not effects.
Further findings
Features of uniquely classified cases
- Patients solely satisfying EULAR/ACR criteria had <4 manifestations
- Majority classified only by 1997 ACR criteria did not meet any defined immunologic criteria
- Patients fulfilling only SLICC criteria did so based on features unique to this system
Original publication
Evaluation of the EULAR /American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus in a Population‐Based Registry. Arthritis Care Res (Hoboken). Published 11 January 2023. doi:10.
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