Lupus & antiphospholipid syndrome
Longitudinal associations of flare and damage accrual in patients with systemic lupus erythematosus
Authors' conclusion
Flares independently increased the risk of damage accrual.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) in the Asia Pacific Lupus Collaboration cohort with ≥3 years of prospectively captured datamedian follow-up 5.7 years
- Participants
- 1,556 patients
- Exposure
- Flares vs no flares
- Outcome
- Damage accrual (SLICC/ACR DI, assessed annually)
Methodological detailsmultivariable, multifailure survival analyses
- Multivariable, multifailure survival analyses
Main finding
As reported in the abstract
Subsequent damage accrual
Each group vs no flaresEstimate (95% CI)
Mild-to-moderate flare32% greater risk
aHR 1.32(1.17–1.72)
Severe flare
HR 1.58(1.18–2.11)
- Per additional flare, HR (95% CI 1.02 to 1.13); risk increased by 7%
- 1.07
Observational data: associations, not effects.
Further findings
Prevalence of damage and flares; damage incidence
- Damage at enrolment, % (n=614)
- 39.5%
- Accrued damage during observation, % (n=496)
- 31.9%
- Incidence of damage accrual, per 1000 person-years
- ≈58
- Any flare at least once, % (n=1153)
- 74.1%
- Recurrent (≥2) flares, % (n=885)
- 56.9%
Original publication
Longitudinal associations of flare and damage accrual in patients with systemic lupus erythematosus. Lupus Sci Med. Published 19 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →