Lupus & antiphospholipid syndrome
Mucocutaneous Disease Activity and Damage Accrual in Systemic Lupus Erythematosus: Analyses From the Asia‐Pacific Lupus Collaboration Longitudinal Cohort Study
Authors' conclusion
All mucocutaneous manifestations were associated with worse HRQoL. MC-A correlated with serologic and systemic disease activity burden in SLE. Persistent MC-A was associated with increased risk of MC-D
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) in the Asia-Pacific Lupus Collaboration cohort, 2013–2021median 2.5 years' follow-up
- Participants
- 4,102 patients
- Exposure
- Patients with vs without mucocutaneous activity or damage
- Outcome
- Prevalence of MC-A (rash, alopecia, mucosal ulcers; SLEDAI-2K) and of MC-D (SLICC/ACR DI), their associations and health-related quality of life (HRQoL) impact (SF-36)
Methodological detailsmulticentre (Asia-Pacific Lupus Collaboration), multivariate logistic generalized estimating equation models, time-varying covariate survival models
- Multicentre (Asia-Pacific Lupus Collaboration)
- Multivariate logistic generalized estimating equation models
- Time-varying covariate survival models
Main finding
As reported in the abstract
Prevalence of MC-A · median 2.5 (IQR 1.0-5.1) years' follow-up
- Mucocutaneous activity (MC-A)
- 1,499 of 4,102 patients (36.5%)
- Rash
- 1,055
- Alopecia
- 731
- Mucosal ulcers
- 352
- Persistent MC-A
- 606 of 3,655 patients (16.6%)
- Mucocutaneous damage (MC-D) accrued
- 157 of 3,647 (4.3%)
- MC-D skin/panniculum scarring
- 53
- MC-D alopecia
- 98
- MC-D ulceration
- 30
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| SF-36 scores, patients with MC-A vs withoutMC-A vs No MC-A | mean mental component SF-36 42.6 vs 44.8 | P = 0.014 |
| SF-36 scores, patients with MC-A vs withoutMC-A vs No MC-A | mean physical component SF-36 41.1 vs 46.1 | P < 0.001 |
| SF-36 physical component score, patients with MC-D vs without | mean physical component SF-36 39.8 vs 46.0 | P = 0.001 |
Correlates of MC-A
- Being White, smoking, serologic activity, vasculitis, myositis, serositis, nephritis, and neurologic/psychiatric features were correlates of MC-A
Predictors of MC-D
- Patients with MC-D more likely to be White with persistent MC-A
Original publication
Mucocutaneous Disease Activity and Damage Accrual in Systemic Lupus Erythematosus: Analyses From the Asia‐Pacific Lupus Collaboration Longitudinal Cohort Study. Arthritis Care Res (Hoboken). Published 10 May 2026. doi:10.
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