Lupus & antiphospholipid syndrome
Age-related patterns of organ damage impact on health-related quality of life in SLE
Authors' conclusion
Age-related differences in SLE predominantly affect physical rather than mental aspects of HRQoL. Cumulative organ damage remains a central modifiable factor associated with poorer outcomes across all ages.
Study context
- Population
- Patients with SLE from the Asia Pacific Lupus Collaboration cohort, stratified by age
- Participants
- 1,149 patients
- Exposure
- Age groups ≥50 years vs <20 years and 20-50 years
- Outcome
- Health-related quality of life (HRQoL) (Short Form-36): Physical (PCS) and Mental Component Summary (MCS) scores
Methodological detailsmultiple linear regression
- Multiple linear regression
Main finding
As reported in the abstract
PCS score by age group
≥50 years
52.6
median
<20 years
56.9
20-50 years
57.5
P < 0.001
Observational data: associations, not effects.
Further findings
Factors independently associated with PCS (multivariable)
- Higher Systemic Lupus International Collaborating Clinics (SLICC) Damage Index (β)
- −1.39
- Lower educational attainment (β)
- −7.02
- Prednisolone use (β)
- −1.85
Factors associated with Mental Component Summary (MCS)
- Male gender (β)
- 4.40
- Secondary education (β)
- 2.46
- Higher damage index (β)
- −0.90
- Cyclophosphamide use (β)
- −5.44
Specific damage patterns
- Avascular necrosis particularly impaired bodily pain and physical functioning domains
Original publication
Age-related patterns of organ damage impact on health-related quality of life in SLE. Lupus Sci Med. Published 31 December 2025. doi:10.
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