Lupus & antiphospholipid syndrome
Central nervous system involvement in systemic lupus erythematosus: Data from the Spanish Society of Rheumatology Lupus Register (RELESSER)
Main finding · Major CNS NP-SLE: prevalence and mortalityResult — go to the resultHazard ratio 1.85 CI 1.29–2.67Authors' conclusion
The presentation of major CNS NP-SLE during the disease course contributes to a higher mortality, which may differ depending on the individual NP manifestation. CVD and organic brain syndrome are associated with the highest mortality rates.
Study context
- Population
- Patients fulfilling the 1997 ACR systemic lupus erythematosus (SLE) classification criteria in the Spanish Society of Rheumatology Lupus Register (RELESSER-TRANS)
- Participants
- 3,591 SLE patients
- Exposure
- Patients with vs without ever major central nervous system (CNS) NP-SLE
- Major CNS NP-SLEn = 412
- Outcome
- Prevalence, incidence, survival and contribution to mortality of major CNS NP-SLE
Methodological detailsmulticentre, register-based, Cox regression adjusted for confounders
- Multicentre
- Register-based
- Cox regression adjusted for confounders
Main finding
Major CNS NP-SLE: prevalence and mortality
Hazard ratio
1.85
CI 1.29–2.67
Events by group
Major CNS NP-SLE
11.5%
412
Without major CNS NP-SLE
- Annual mortality rate
- 3.8%
- Years to 10% mortality rate
- 22.8
Major CNS NP-SLEvs Without major CNS NP-SLE
HR 1.85 (CI 1.29–2.67)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mortality by individual manifestation: Cerebrovascular disease (CVD)
| HR (CI) | ||
|---|---|---|
| CVD | 2.17 (1.41–3.33) | |
| 0.20.5125Hazard ratio (log scale) |
Mortality by individual manifestation: organic brain syndrome
| HR (CI) | ||
|---|---|---|
| Organic brain syndrome | 2.11 (1.19–3.74) | |
| 0.20.5125Hazard ratio (log scale) |
- Mortality by individual manifestation: CVD — Mortality rate
- 14%
- Mortality by individual manifestation: CVD — Years to 10% mortality rate
- 9.8
- Mortality by individual manifestation: organic brain syndrome — Mortality rate
- 15.5%
- Mortality by individual manifestation: organic brain syndrome — Years to 10% mortality rate
- 7.1
Original publication
Central nervous system involvement in systemic lupus erythematosus: Data from the Spanish Society of Rheumatology Lupus Register (RELESSER). Semin Arthritis Rheum. Published 22 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →