Lupus & antiphospholipid syndrome
Association of Systemic Lupus International Collaborating Clinics Frailty Index With Damage in Systemic Lupus Erythematosus Patients: Results From a Multiethnic, Multicenter US Cohort of Patients With Lupus
Main finding · Damage accrual (change in SDI) per 0.05 increase in baseline SLICC-FI, multivariable modelResult — go to the resultIncidence rate ratio 1.20 95% CI 1.08–1.33Authors' conclusion
The SLICC-FI is associated with damage accrual in SLE patients from a multiethnic cohort
Study context
- Population
- Systemic lupus erythematosus (SLE) patients from the multiethnic, multicenter LUMINA cohort454 (90.3%) female
- Participants
- 503 patients
- Exposure
- Baseline Systemic Lupus International Collaborating Clinics frailty index (SLICC-FI) score
- Outcome
- Change in SDI score (difference between last and baseline SDI score)
- Follow-up
- Last visit
Methodological detailsmultiethnic, multicenter, negative binomial regression
- Multiethnic
- Multicenter
- Negative binomial regression
Main finding
As reported in the abstract
Damage accrual (change in SDI) per 0.05 increase in baseline SLICC-FI, multivariable model
Incidence rate ratio
1.20
95% CI 1.08–1.33
P = 0.0015
SLICC-FI per 0.05 increase
IRR 1.20 (95% CI 1.08–1.33); P = 0.0015
Per 0.05 increase, as printed
- Baseline SLICC-FI score, mean ± SD
- 0.26 ± 0.06
- Baseline SDI score, mean ± SD
- 0.6 ± 1.0
- Change in SDI score, mean ± SD
- 1.9 ± 2.2
Observational data: associations, not effects.
Original publication
Association of Systemic Lupus International Collaborating Clinics Frailty Index With Damage in Systemic Lupus Erythematosus Patients: Results From a Multiethnic, Multicenter US Cohort of Patients With Lupus. Arthritis Care Res (Hoboken). Published 20 October 2022. doi:10.
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