Lupus & antiphospholipid syndrome
Systemic Lupus International Collaborating Clinics Frailty Index predicts mortality in systemic lupus erythematosus patients: data from the Almenara Lupus Cohort
Main finding · MortalityResult — go to the resultHazard ratio 1.54 95% CI 1.11–2.14Authors' conclusion
Frailty, as ascertained with the SLICC-FI, was a predictor of mortality in a Latin American cohort of SLE patients.
Study context
- Population
- Latin American systemic lupus erythematosus (SLE) patients, single-centre 2012–2025 prevalent cohort (Almenara Lupus Cohort), Peru96 (19.4%) frail
- Participants
- 495 patients
- Exposure
- Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) as predictor of mortality
- Outcome
- Mortality (vital status per Peruvian Department of Health)
Methodological detailssingle-centre, prevalent cohort, univariable and multivariable Cox regression, sensitivity analysis up to March 2020
- Single-centre
- Prevalent cohort
- Univariable and multivariable Cox regression
- Sensitivity analysis up to March 2020
Main finding
Mortality
Hazard ratio
1.54
95% CI 1.11–2.14
P = 0.010
SLICC-FI
HR 1.54 (95% CI 1.11–2.14); P = 0.010
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mortality, sensitivity analysis (data up to March 2020, pre-COVID-19)
| HR (95% CI) | P value | ||
|---|---|---|---|
| SLICC-FI | 1.85 (1.30–2.61) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Systemic Lupus International Collaborating Clinics Frailty Index predicts mortality in systemic lupus erythematosus patients: data from the Almenara Lupus Cohort. Lupus Sci Med. Published 12 June 2026. doi:10.
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