Lupus & antiphospholipid syndrome
Systemic Lupus International Collaborating Clinics Frailty Index Predicts Worsening Health‐Related Quality of Life, Data From the Almenara Lupus Cohort
Authors' conclusion
Higher SLICC-FI scores predicted worse health-related QoL as measured by higher LupusQoL scores from patients from the Almenara lupus cohort.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) from a single-centre prevalent Latin American Mestizo cohort (Almenara lupus cohort)
- Participants
- 428 patients2,645 visits
- Exposure
- Higher vs lower Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) scores
- Outcome
- Association of SLICC-FI scores with future quality of life (QoL) (main analysis: SLICC-FI as continuous variable vs LupusQoL domains)
Methodological detailssingle-centre, generalized estimating equations, multivariable adjusted
- Single-centre
- Generalized estimating equations
- Multivariable adjusted
Main finding
As reported in the abstract
LupusQoL domains by SLICC-FI (continuous), adjusted
- Higher SLICC-FI scores predicted a higher LupusQoL score in the domains of pain, planning, emotional health, and fatigue
- Main analysis, adjusted for possible confounders
Observational data: associations, not effects.
Further findings
LupusQoL domains by SLICC-FI category (alternative analyses), adjusted
- Frail and least fit categories predictive of higher LupusQoL scores in the fatigue domain
- Frailty (SLICC-FI >0.21) predicted worse body image vs least fit (SLICC-FI 0.03-0.10)
Baseline characteristics
- Disease duration, mean ± SD (years)
- 7.2 ± 6.6
- SDI score, mean ± SD
- 1.0 ± 1.3
- SLICC-FI score, mean ± SD
- 0.17 ± 0.05
- Follow-up (years)
- 4.71 ± 3.52
Original publication
Systemic Lupus International Collaborating Clinics Frailty Index Predicts Worsening Health‐Related Quality of Life, Data From the Almenara Lupus Cohort. Arthritis Care Res (Hoboken). Published 4 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →