Lupus & antiphospholipid syndrome
Baseline characteristics of patients with SLE with and without lupus nephritis from the Latin American multiethnic GLADEL 2.0 cohort
Authors' conclusion
Male sex, Mestizo ethnicity, comorbidities, thrombocytopenia, anti-dsDNA positivity and low complement levels were associated with LN occurrence. Cumulative damage was associated with older age at diagnosis, longer disease duration, higher cumulative dose of prednisone and the use of cyclophosphamide.
Study context
- Population
- Adults (≥18 years) with SLE fulfilling 1982/1997 American College of Rheumatology (ACR) and/or 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, 43 centres in 10 Latin American countries653 with lupus nephritis (LN)
- Participants
- 1,083 adults
- Exposure
- SLE with LN vs without LN
- Outcome
- Factors associated with LN and cumulative damage (SDI)
- Follow-up
- Baseline
Methodological detailsmultinational, multiethnic, multicentre, prevalent and incident cohort, logistic regression
- Multinational
- Multiethnic
- Multicentre
- Prevalent and incident cohort
- Logistic regression
Main finding
As reported in the abstract
Factors associated with LN (logistic regression)
- Older age at diagnosis (OR)
- 0.98
- Discoid rash (OR)
- 0.53
- Male gender (OR)
- 1.91
- Mestizo ethnicity (OR)
- 1.46
- Comorbidities (OR)
- 3.2
- Thrombocytopenia (OR)
- 3.44
- Anti-dsDNA positivity (OR)
- 3.23
- Low complement (OR)
- 1.54
Observational data: associations, not effects.
Further findings
Factors associated with SLICC/ACR Damage Index (SDI) ≥1 · baseline
- SDI ≥1 associated with older age at diagnosis, longer disease duration, cumulative prednisone dose and cyclophosphamide use
Cohort characteristics · baseline
- Female
- 89.6%
- Median age at diagnosis (years)
- 27
- Median disease duration (months)
- 66.2
- Mestizo
- 65.0%
Original publication
Baseline characteristics of patients with SLE with and without lupus nephritis from the Latin American multiethnic GLADEL 2.0 cohort. Lupus Sci Med. Published 20 April 2026. doi:10.
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