Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Smith, MA; Sinibaldi, D; Rahman, S; Chiang, CC; Hansen, AM; Henault, J; Roca, CP; Wang, S; Zerrouki, K; Filippi, R; Groves, C; Manna, Z; Chu, J; Davis, M; Gupta, S; Morehouse, C; de Los Reyes, M; Ettinger, R; Kolbeck, R; Kaplan, MJ; Sanjuan, MA; Siegel, RM; Hasni, SA; Casey, KA

doi:10.1002/art.70105

Lupus & antiphospholipid syndrome

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis RheumatolPublished 20 Apr 2026Mechanistic study

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Authors' conclusion

Together, these results reveal parallel immune mechanisms in SLE and provide a framework to identify new therapeutic targets.

Study context

Population: Patients with systemic lupus erythematosus (SLE)
Participants: 87 patients

Outcome: Protein signatures from integrated multidimensional profiling

Methodological detailsmulti-omic integration

Multi-omic integration

Main finding

As reported in the abstract

Combined prevalence of the protein signatures

94%

Reference

Authors: Smith MA, Sinibaldi D, Rahman S, Chiang CC, Hansen AM, Henault J, et al.
All 24 authors
Smith MA, Sinibaldi D, Rahman S, Chiang CC, Hansen AM, Henault J, Roca CP, Wang S, Zerrouki K, Filippi R, Groves C, Manna Z, Chu J, Davis M, Gupta S, Morehouse C, de Los Reyes M, Ettinger R, Kolbeck R, Kaplan MJ, Sanjuan MA, Siegel RM, Hasni SA, Casey KA
Journal: Arthritis & Rheumatology
Published: 20 Apr 2026
DOI: 10.1002/art.70105
PubMed: 41733120

Topic: Lupus & antiphospholipid syndrome

Key notes

Three independent protein signatures corresponding to discrete organ pathologies and immune perturbations
Previously uncharacterized immune cell priming protein signature, alongside type I interferon and granulocyte pathways, enriched in renal involvement and indicative of elevated risk of six-year organ damage accrual

More notes

Immune cell priming signature outperformed conventional assessments; found only in serum proteomics data

Original publication

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis. Arthritis Rheumatol. Published 20 April 2026. doi:10.1002/art.70105

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