Lupus & antiphospholipid syndrome
Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus
Authors' conclusion
Our longitudinal profiling provides single-cell resolution of the shifts in immune cell dynamics following B cell depletion.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) treated with RTX169,513 immune cells profiled
- Comparison
- SLE patients treated with RTX vs healthy controls
- SLEn = nine
- Healthy controlsn = eightreference
- Outcome
- Immune cell dynamics of B cell depletion and repopulation after RTX
Methodological detailslongitudinal, single-cell profiling
- Longitudinal
- Single-cell profiling
Main finding
As reported in the abstract
- Non-B cells: differentially expressed genes post-RTX across seven immune cell subtypes, most changes in regulatory CD4 T cells and double negative (DN) T cells
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Original publication
Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus. Arthritis Rheumatol. Published 20 April 2026. doi:10.
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