Lupus & antiphospholipid syndrome
Integrated immune profiling identifies a coordinated T-cell activation and inflammatory signature in SLE
Authors' conclusion
Patients with SLE with renal involvement show coordinated disturbances in T-cell and B-cell compartments linked to chronic immune activation, interferon-related responses and disease duration.
Study context
- Population
- Patients with SLE with renal involvement and healthy controls
- Comparison
- SLE with lupus nephritis vs healthy controls
- Outcome
- Peripheral blood immune cell subpopulations and molecular profiles
Methodological detailsflow cytometry, quantitative PCR, exploratory multivariate and treatment-sensitivity analyses
- Flow cytometry
- Quantitative PCR
- Exploratory multivariate and treatment-sensitivity analyses
Main finding
As reported in the abstract
- Decreased proportion of Th cells and increased percentage of Tc cells in SLE vs HC, with reduced CD4/CD8 ratio
- Lower percentages of CD4+CD28+ and CD8+CD28+ T cells, correlated with disease duration
- Increased proportions of activated HLA-DR+ Th and Tc cells
- Elevated serum IL-6 and IL-10 in SLE
- Increased expression in T and B cells of inflammatory and interferon-related genes, incl. TBX21, APOBEC3G, IRF8 and ISG15
Further findings
Exploratory multivariate profiling
- Coordinated immune activation in SLE: enhanced T-cell activation, elevated inflammatory cytokines, plasmablast expansion, reduced CD28+ T-cell subsets
- Exploratory
Treatment-sensitivity analyses
- Selected immune parameters may be influenced by GC exposure and disease duration
Original publication
Integrated immune profiling identifies a coordinated T-cell activation and inflammatory signature in SLE. Lupus Sci Med. Published 15 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →