Lupus & antiphospholipid syndrome
The Role of Anti‐Phosphatidylserine/Prothrombin Antibodies and the Lectin Complement Pathway in Anti‐Phospholipid Antibody‐Associated Preterm Delivery
Authors' conclusion
The reduced LP activity and the higher anti-PS/PT IgG/IgM titers in PTD aPL-positive women during the first trimester suggest their use as early prognostic tools for PTD in aPL-positive pregnant women.
Study context
- Population
- Women observed prospectively during pregnancy and postpartum, aPL-positive (antiphospholipid syndrome (APS) or aPL-carriers) and aPL-negative (SLE, RA, UCTD)231 available specimens
- Participants
- 60 women
- Exposure
- aPL-positive vs aPL-negative pregnant women; Preterm delivery (PTD) vs non-PTD
- aPL-positiven = 33
- aPL-negativen = 27reference
- Outcome
- Prognostic value of classification/nonclassification laboratory APS criteria and complement activation markers for pregnancy complications, in particular preterm delivery (PTD)
Main finding
As reported in the abstract
PTD
Observational data: associations, not effects.
Further findings
Anti-PS/PT IgG/IgM titers, PTD vs non-PTD · almost all time points
- Significantly higher in PTD vs non-PTD women
- P < 0.05
LP activity in aPL-positive PTD
- Lower than in non-PTD (unlike CP and AP); significantly different vs aPL-negative PTD
- P < 0.05
Correlations (first trimester)
- LP activity significantly correlated with anti-PS/PT IgG/IgM titers
- P < 0.05
- All significantly correlated with week of gestation at delivery
- P < 0.05
Original publication
The Role of Anti‐Phosphatidylserine/Prothrombin Antibodies and the Lectin Complement Pathway in Anti‐Phospholipid Antibody‐Associated Preterm Delivery. Arthritis Rheumatol. Published 13 July 2026. doi:10.
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