Lupus & antiphospholipid syndrome
Assessing the mortality burden after acute myocardial infarction in SLE: insights from the MINAP Registry
Main finding · Adjusted all-cause mortalityResult — go to the resultHazard ratio 1.84 95% CI 1.63–2.09Authors' conclusion
Individuals with SLE have a persistently higher risk of all-cause and cardiovascular mortality following AMI, despite being younger and having less traditional cardiovascular comorbidities.
Study context
- Population
- Adults hospitalised with acute myocardial infarction (AMI) between January 2005 and March 2019 (MINAP registry)715 (0.1%) with SLE
- Participants
- 784,091 adults
- Exposure
- SLE vs no SLE after AMI
- SLEn = 715
- Outcome
- Long-term all-cause mortality after AMI
- Follow-up
- Up to 5 years
Methodological detailsnational registry (MINAP) linked with Hospital Episode Statistics and Office for National Statistics mortality records, adjusted analysis
- National registry (MINAP) linked with Hospital Episode Statistics and Office for National Statistics mortality records
- Adjusted analysis
Main finding
Adjusted all-cause mortality
Hazard ratio
1.84
95% CI 1.63–2.09
P < 0.001
SLEvs Without SLE
HR 1.84 (95% CI 1.63–2.09); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Adjusted all-cause mortality · 30 daysAdjusted | 1.62 (1.23–2.12) | P = 0.001 | |
| 0.512Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Assessing the mortality burden after acute myocardial infarction in SLE: insights from the MINAP Registry. Rheumatology (Oxford). Published 11 July 2026. doi:10.
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