Lupus & antiphospholipid syndrome
Disparities in severe infection risk associated with SLE: evidence from a causal forest analysis
Authors' conclusion
Significant disparities exist in the excess infection risk associated with SLE.
Study context
- Population
- Health administrative data from British Columbia, Canada (1990–2024)matched cohort
- Participants
- 10,517 vs 52,585
- Exposure
- Incident SLE vs matched non-SLE controls
- SLEn = 10,517
- Non-SLE controlsn = 52,585reference
- Outcome
- Heterogeneity in the excess severe infection rate due to SLE and key patient-level risk modifiers
Methodological detailsmatched 1:5 on birth year, sex and index year, causal forest analysis, generalized additive models
- Matched 1:5 on birth year, sex and index year
- Causal forest analysis
- Generalized additive models
Main finding
As reported in the abstract
Individual-level excess risk of severe infection among SLE patients (causal forests)
| Group | Value | SD across individuals |
|---|---|---|
| SLE | average 21.12 (SE 3.14) per 1000 person-years | 19.73 per 1000 person-years |
SLE
Valueaverage 21.12 (SE 3.14) per 1000 person-years
SD across individuals19.73 per 1000 person-years
Observational data: associations, not effects.
Original publication
Disparities in severe infection risk associated with SLE: evidence from a causal forest analysis. Rheumatology (Oxford). Published 11 July 2026. doi:10.
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