Lupus & antiphospholipid syndrome
Serum interferon-alpha predicts in-hospital mortality in patients hospitalised with acute severe lupus
Authors' conclusion
Serum IFN-α was better in predicting in-hospital mortality compared with conventional measures of disease activity such as anti-dsDNA, complements and SLEDAI.
Study context
- Population
- Patients hospitalised for acute severe SLE (mean Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) 19.3), tertiary care rheumatology unit in India
- Participants
- 90 patients
- Comparison
- Serum IFN-α vs conventional disease activity markers (SLEDAI, anti-dsDNA, C3) for predicting in-hospital mortality
- Outcome
- In-hospital mortality (predictive performance of serum IFN-α)
- Follow-up
- In-hospital
Methodological detailssingle-centre, tertiary care rheumatology unit
- Single-centre
- Tertiary care rheumatology unit
Performance
As reported in the abstract
Prediction of in-hospital mortality
| Test or model | Sensitivity (cut-off 140 pg/mL) | Specificity | PPV | NPV | P | AUC |
|---|---|---|---|---|---|---|
| Serum IFN-α | 86.7% | 94.6% | 76% | 83.3% | p<0.001 | 0.92 |
| SLEDAI | 0.77 | |||||
| anti-dsDNA | 0.72 | |||||
| C3 | 0.25 |
Sensitivity (cut-off 140 pg/mL)
Serum IFN-α86.7%
SLEDAI— not stated in the abstract
anti-dsDNA— not stated in the abstract
C3— not stated in the abstract
Specificity
Serum IFN-α94.6%
SLEDAI— not stated in the abstract
anti-dsDNA— not stated in the abstract
C3— not stated in the abstract
PPV
Serum IFN-α76%
SLEDAI— not stated in the abstract
anti-dsDNA— not stated in the abstract
C3— not stated in the abstract
NPV
Serum IFN-α83.3%
SLEDAI— not stated in the abstract
anti-dsDNA— not stated in the abstract
C3— not stated in the abstract
P
Serum IFN-αp<0.001
SLEDAI— not stated in the abstract
anti-dsDNA— not stated in the abstract
C3— not stated in the abstract
AUC
Serum IFN-α0.92
SLEDAI0.77
anti-dsDNA0.72
C30.25
Further findings
Serum IFN-α level in the cohort
- Mean serum IFN-α
- 88±144 pg/dL
- Levels undetectable in patients with inactive disease
Markers in non-survivors vs survivors
- SLEDAI higher in non-survivors
- P = 0.003
- Anti-dsDNA titres higher in non-survivors
- P = 0.017
- Serum IFN-α higher in non-survivors
- P < 0.001
- Serum C3 lower in non-survivors
- P = 0.029
Original publication
Serum interferon-alpha predicts in-hospital mortality in patients hospitalised with acute severe lupus. Lupus Sci Med. Published 4 September 2023. doi:10.
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