Lupus & antiphospholipid syndrome
Serum IgA autoantibody profiling in systemic lupus erythematosus reveals associations with disease phenotypes
Authors' conclusion
Clustering according to IgA autoantibody profiles suggests the presence of a subgroup of patients with SLE associated with Asian ethnicity, lupus nephritis and immunosuppression use. Additionally, a novel association between anti-STAM2 IgA and haematological disease was discovered.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE); 1613 serum IgA autoantibodies quantified, incl. antibodies against IFNα1, IFNω and IFNγ
- Participants
- 60 patients
- Exposure
- Cluster 1 vs Cluster 2 vs Cluster 3 vs Cluster 4 vs Cluster 5
- Outcome
- Associations between serum IgA autoantibody profiles and SLE clinical phenotypes
Methodological detailsi-Ome protein array, clustering analysis, multinomial logistic regression, differential abundance analysis, supervised learning
- i-Ome protein array
- Clustering analysis
- Multinomial logistic regression
- Differential abundance analysis
- Supervised learning
Main finding
As reported in the abstract
Five patient clusters identified
5
Observational data: associations, not effects.
Original publication
Serum IgA autoantibody profiling in systemic lupus erythematosus reveals associations with disease phenotypes. RMD Open. Published 15 July 2026. doi:10.
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