Autoantibody clusters in childhood-onset systemic lupus erythematosus: Insights from a multicenter study with 912 patients
Authors' conclusion
Our study suggests that, within the context of cSLE, the coexistence of anti-dsDNA with antiphospholipid autoantibodies is linked to an elevated incidence of antiphospholipid syndrome. This association does not coincide with a proportionate increase in the occurrence of nephritis. Conversely, the cluster of anti-dsDNA with anti-Ro/SSA and anti-La/SSB antibodies was associated with pulmonary damage, requiring close surveillance.
Study context
- Population
- cSLE patients, 27 Pediatric Rheumatology University centers
- Participants
- 912 patients27 centres
- Exposure
- Four autoantibody clusters compared with each other
- Cluster 1n = 322
- Cluster 2n = 158
- Cluster 3n = 177
- Cluster 4n = 255
- Outcome
- Clusters of autoantibodies (anti-dsDNA, anti-Ro/SSA, anti-La/SSB, anti-Sm, anti-RNP, aCL IgM and/or IgG and LA) and their associations with demographics, cumulative clinical and laboratory manifestations, disease activity, cumulative damage and mortality
Methodological detailsmulticentre, K-means cluster analysis
- Multicentre
- K-means cluster analysis
Main finding
As reported in the abstract
- Cluster 1: lower frequency of cutaneous, articular manifestation vs other groups
- P < 0.05
- Cluster 1: lower frequency of hypocomplementemia vs other groups
- P < 0.001
- Cluster 2: higher frequency of thrombocytopenia than other clusters
- P = 0.006
- Cluster 2: higher frequency of APS than other clusters
- P < 0.001
- Cluster 4: no specific clinical pattern, except higher pulmonary damage
- P = 0.017
Observational data: associations, not effects.
Further findings
Proteinuria (Cluster 3 higher vs Cluster 4)
P = 0.031
Original publication
Autoantibody clusters in childhood-onset systemic lupus erythematosus: Insights from a multicenter study with 912 patients. Lupus. Published 27 January 2025. doi:10.
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