Joint fluid multi-omics improves diagnostic confidence during evaluation of children with presumed septic arthritis
Authors' conclusion
The multiomics approach rapidly identified children with bacterial or autoimmune inflammatory conditions, improving diagnostic and treatment strategies for those with presumptive septic arthritis.
Study context
- Population
- Children with suspected septic arthritis (10 suspected primary septic arthritis, 2 acute hematogenous osteomyelitis)
- Participants
- 12 children
- Comparison
- Rapid multi-omics approach vs standard of care tests
- Outcome
- Diagnostic value of multi-omics relative to standard of care culture and PCR-negative results
Methodological detailsmulti-omics (16S rRNA metagenomics, single cell transcriptomics, proteomics)
- Multi-omics (16S rRNA metagenomics, single cell transcriptomics, proteomics)
Performance
As reported in the abstract
Improved diagnostic confidence with multi-omics
- Children with improved diagnostic confidence
- 9 of 12 (75%)
- 16S DNA sequencing distinct between children with and without infections
- p = 0.006
- Cytokine assays distinct between children with and without infections
- p = 0.009
- Autoantibody profiling distinct between children with and without infections
- p = 0.02
Original publication
Joint fluid multi-omics improves diagnostic confidence during evaluation of children with presumed septic arthritis. Pediatr Rheumatol Online J. Published 24 January 2025. doi:10.
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