Lupus & antiphospholipid syndrome
Implications of serum calcitonin gene-related peptide and type I interferon in systemic lupus erythematosus-associated headaches
Authors' conclusion
Serum CGRP and type I IFNs levels may not be involved in SLE-associated headaches.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) from a Japanese multicenter cohort and a biobankplus 20 healthy controls (HC)
- Participants
- 144 patients
- Exposure
- SLE with headache vs SLE without headache vs healthy controls
- Headachen = 60
- HCn = 20reference
- Outcome
- Serum CGRP, IFN-α and IFN-β levels (enzyme-linked immunoassay) as headache biomarkers
Methodological detailsmulticentre cohort and biobank
- Multicentre cohort and biobank
Main finding
As reported in the abstract
Serum CGRP, IFN-α and IFN-β levels
- Serum calcitonin gene-related peptide (CGRP) and interferon (IFN)-α levels not significantly different between patients with headache, those without headache, and HC
- Headache vs Without headache: P < 0.005
- Headache vs HC: P < 0.005
- Without headache vs HC: P < 0.005
Observational data: associations, not effects.
Further findings
| Outcome | Headache | Without headache | P value |
|---|---|---|---|
| Age (median)Headache vs Without headache · significantly younger · years | 42 | 49 | P < 0.005 |
| SLEDAI-2K score (median) | 4.0 | 4.0 |
- Photosensitivity · Headache vs Without headache
- P < 0.05
SLEDAI-2K score (median)
- Not significantly different
Serum CGRP, IFN-α and IFN-β by severity of headache-related daily disability (Migraine Disability Assessment)
- No significant differences
Original publication
Implications of serum calcitonin gene-related peptide and type I interferon in systemic lupus erythematosus-associated headaches. Lupus. Published 3 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →