Lupus & antiphospholipid syndrome
High disease activity persists in adults with childhood-onset lupus
Authors' conclusion
Adults with cSLE entered adult follow-up with higher baseline damage and continued to experience a higher longitudinal disease activity burden than patients with aSLE.
Study context
- Population
- Adults with SLE enrolled in the Australian Lupus Registry and Biobank 2011–2022 with ≥12 months of data; median (IQR) age 39 (30–51) years; 88.1% female68 (13%) cSLE
- Participants
- 519 adults
- Exposure
- Childhood-onset SLE vs adult-onset SLE, in adulthood
- cSLEn = 68
- Outcome
- Key outcomes: SLEDAI-2K AMS, time in Lupus Low Disease Activity State (LLDAS) and damage accrual
Methodological detailsnational registry (Australian Lupus Registry and Biobank), longitudinal, Bivariate tests for group comparisons
- National registry (Australian Lupus Registry and Biobank)
- Longitudinal
- Bivariate tests for group comparisons
Main finding
As reported in the abstract
Disease activity, SLEDAI-2K AMS · median (IQR) follow-up 5 (2.6-9.3) years
cSLE
5.0
median · IQR 3.0–6.4
aSLE
3.6
median · IQR 1.9–5.1
P < 0.001
Observational data: associations, not effects.
Further findings
Achievement of LLDAS-50
P = 0.036
Baseline damage (SDI≥1)
P = 0.05
Baseline renal involvement
P < 0.001
High Disease Activity Status (SLEDAI-2K ≥10 ever)
- cSLE more likely to be in High Disease Activity Status
Damage accrual, flare rates and quality of life during follow-up
- Similar between groups
Original publication
High disease activity persists in adults with childhood-onset lupus. Lupus Sci Med. Published 5 August 2026. doi:10.
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