Lupus & antiphospholipid syndrome
A Brazilian single-centre series comparision of childhood, adult and late onset Systemic lupus Erythematosus
Authors' conclusion
The remarkable differences among the 3-age-groups were higher frequency of renal and neuropsychiatric domains in youngsters and disease activity scores compared to other age-groups. The lSLE group had less nephritis and serositis, lower disease activity and higher damage scores.
Study context
- Population
- SLE cases seen between 2012 and 2022 at a single Brazilian centre
- Participants
- 415 single-centre series
- Exposure
- Childhood-onset vs adult-onset vs late-onset SLE
- cSLEn = 79
- aSLEn = 289reference
- lSLEn = 47
- Outcome
- Clinical profile, disease activity, remission and damage by age at onset
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Most common clinical manifestations (whole cohort)
- Articular
- 75.2%
- Hematological
- 70.1%
- Cutaneous
- 67.9%
- Photosensitivity
- 59.3%
- Renal
- 41.7%
Original publication
A Brazilian single-centre series comparision of childhood, adult and late onset Systemic lupus Erythematosus. Lupus. Published 8 August 2025. doi:10.
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