Lupus & antiphospholipid syndrome
Association of lupus low disease activity state and remission with reduced organ damage and flare in systemic lupus erythematosus patients with high disease activity: a multi-national, longitudinal cohort study
Authors' conclusion
LLDAS and REM were achievable targets in HDAS patients, and provided significant protection against adverse outcomes.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients with high disease activity status (HDAS; SLEDAI-2K ≥ 10), multinational cohort, 2013–2020
- Participants
- 726 vs 418
- Exposure
- Attainment of cumulative and sustained lupus low disease activity state (LLDAS) or remission (REM) vs non-attainment in HDAS patients
- LLDAS-evern = 726
- REM-evern = 418
- Outcome
- Frequency of LLDAS and REM attainment in HDAS patients and association with subsequent organ damage accrual and flare
Methodological detailsmultinational, longitudinal, survival analyses
- Multinational
- Longitudinal
- Survival analyses
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Sustained LLDAS ≥3 months
- Patients attaining ≥3 months sustained LLDAS
- 37% (n = 385)
- Lower proportions attained sustained REM
≥50% cumulative time in LLDAS or REM
- Approximately one-fifth of patients
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of lupus low disease activity state and remission with reduced organ damage and flare in systemic lupus erythematosus patients with high disease activity: a multi-national, longitudinal cohort study. Rheumatology (Oxford). Published 4 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →