Lupus & antiphospholipid syndrome
Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus
Authors' conclusion
Elevated IFN-α protein in plasma of women with SLE is a potential risk factor for lower birth weight of their infants.
Study context
- Population
- Pregnant women with SLE; plasma IFN-α measured in second and third trimester
- Participants
- 76 women
- Outcome
- IFN-α and adverse pregnancy outcomes
Main finding
As reported in the abstract
- Women with small for gestational age (SGA) infants vs without had higher plasma IFN-α protein levels
- IFN-α positivity associated with lower birth weight of the infant
Observational data: associations, not effects.
Further findings
Preterm birth
- Preterm birth associated with autoantibodies against chromatin
IFN-α and autoantibodies
- IFN-α levels associated positively with anti-chromatin, anti-SmRNP and anti-RNP, negatively with aPL antibodies
Original publication
Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus. Rheumatology (Oxford). Published 14 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →