Lupus & antiphospholipid syndrome
Racial differences in cardiovascular events and adverse pregnancy outcomes among pregnant individuals with SLE
Authors' conclusion
Non-Hispanic black women exhibited the highest absolute burden for the adverse outcomes studied. Relative to non-Hispanic white individuals, elevated adjusted risks based on race/ethnicity were most consistent for infant APOs, whereas elevated risks for maternal APOs and CVEs were found primarily among non-Hispanic black individuals.
Study context
- Population
- Pregnant individuals with SLE identified via ICD codes from maternal discharge records, California population-based birth cohort (2005–2020)
- Participants
- 8,188 liveborn singletons
- Exposure
- Asian, Hispanic, non-Hispanic black and other vs non-Hispanic white pregnant individuals with SLE
- Outcome
- Maternal cardiovascular events (CVEs) and adverse pregnancy outcomes (APOs) (maternal and infant) by racial/ethnic group
Methodological detailspopulation-based birth cohort, propensity score-adjusted log-linear regression
- Population-based birth cohort
- Propensity score-adjusted log-linear regression
Main finding
As reported in the abstract
Maternal CVEs, maternal APOs and infant APOs
Non-Hispanic black
4.0%
Each group vs Non-Hispanic whiteEstimate (95% CI)
Non-Hispanic black
aRR (maternal CVEs) 1.6(0.9–2.6)
Non-Hispanic black
aRR (maternal APOs) 1.3(1.1–1.6)
- Maternal CVE prevalence in other groups
- 1.6-2.0%
- Maternal APO prevalence in other groups
- 13.5-17.2%
- Infant APO prevalence in other groups
- 34.6-49.4%
Observational data: associations, not effects.
Original publication
Racial differences in cardiovascular events and adverse pregnancy outcomes among pregnant individuals with SLE. Lupus Sci Med. Published 15 September 2026. doi:10.
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