Lupus & antiphospholipid syndrome
Remission, low disease activity and relapse in patients with juvenile-, adult- and late-onset SLE
Main finding · RelapseResult — go to the resultHazard ratio 2.1 95% CI 1.5–2.9Authors' conclusion
jSLE was associated with higher relapse rates, whereas late-onset SLE was independently associated with achieving remission and LLDAS.
Study context
- Population
- Patients classified with SLE by 2019 EULAR/ACR criteria; other autoimmune diseases excluded except APS and Sjögren90.5% female
- Participants
- 289 patients
- Exposure
- Juvenile-onset vs adult-onset vs late-onset SLE
- jSLEn = 96
- aSLEn = 96reference
- lSLEn = 97
- Outcome
- Remission (DORIS), low disease activity (LLDAS) and relapse (SELENA-SLEDAI Flare Index) by age at onset
Main finding
Relapse
Hazard ratio
2.1
95% CI 1.5–2.9
P = 0.008
By group
jSLEvs aSLE
HR 2.1 (95% CI 1.5–2.9); P = 0.008
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Remission (DORIS), predictorslSLEvs aSLElSLE independently predicted remission | HR for achieving remission 2.8 (95% CI 1.9–4.0) | P < 0.001 | |
| LLDAS, predictorslSLEvs aSLElSLE independently predicted LLDAS | HR for achieving LLDAS 2.4 (95% CI 1.7–3.4) | P < 0.001 | |
| 0.20.5125Ratio (log scale) |
Remission (DORIS), predictors
- Remission achieved more frequently in lSLE
LLDAS, predictors
- LLDAS achieved more frequently in lSLE
Original publication
Remission, low disease activity and relapse in patients with juvenile-, adult- and late-onset SLE. Rheumatology (Oxford). Published 15 September 2026. doi:10.
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