Lupus & antiphospholipid syndrome
A large cohort comparison of very late-onset systemic lupus erythematosus with younger-onset patients
Authors' conclusion
Compared with younger patients, in vlSLE, female predominance is less pronounced. Arthritis, anti-dsDNA antibodies and low C3 levels are less frequent. SS and RA are more common. Despite lower disease activity, vlSLE patients have the lowest survival rate.
Study context
- Population
- All patients fulfilling systemic lupus erythematosus (SLE) classification criteria evaluated at a university hospital, 1978–2023
- Participants
- 845 patients
- Exposure
- Very late-onset SLE vs younger-onset SLE
- jSLEn = 153
- aSLEn = 630
- lSLEn = 47
- vlSLEn = 15
- Outcome
- Clinical and serological features of vlSLE vs younger-onset groups
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
| Group | Female-to-male ratio | Caucasian | Survival time | Positive anti-dsDNA | Low C3 | Arthritis | Sjögren's syndrome | RA |
|---|---|---|---|---|---|---|---|---|
| vlSLE | 4:1 | 93.3% | 20.3 years | 26.7% | 13.3% | 73.3% | 33.3% | 13.3% |
vlSLE
Female-to-male ratio4:1
Caucasian93.3%
Survival time20.3 years
Positive anti-dsDNA26.7%
Low C313.3%
Arthritis73.3%
Sjögren's syndrome33.3%
RA13.3%
- Lower female-to-male ratio (tended), p=0.282
- 4:1
- Mainly Caucasian, p<0.001
- 93.3%
- Lowest survival time, p<0.001
- 20.3 years
- Lowest prevalence of positive anti-dsDNA, p=0.010
- 26.7%
- Lowest prevalence of low C3, p<0.001
- 13.3%
- Arthritis less common, p=0.043
- 73.3%
- Sjögren's syndrome more common, p<0.001
- 33.3%
- RA more common, p<0.001
- 13.3%
Observational data: associations, not effects.
Further findings
- Infections and malignancy were the main causes of death
Original publication
A large cohort comparison of very late-onset systemic lupus erythematosus with younger-onset patients. Clin Exp Rheumatol. Published 27 October 2023. doi:10.
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